Description Why is Pro-Gest® Cream so trusted? Maybe because it's been the leader since 1978. For 35 years, women have relied on Pro-Gest® for support at midlife. Our Pro-Gest® 4 oz. value-size tube contains about a two-month supply. Pro-Gest® Cream contains 450 mg of USP Progesterone per ounce (20 mg per 1/4 teaspoon). Our progesterone comes from the Mexican Wild Yam and is converted to pure USP Progesterone (meeting the standards of the United States Pharmacopeia for strength, purity and quality).